Jacob I Sznajder Selected Research

protein kinase C zeta

11/2017	HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury.
9/2014	HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth.
7/2009	Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta.

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Jacob I Sznajder Research Topics

Disease

22	Hypercapnia 01/2021 - 02/2002
21	Hypoxia (Hypoxemia) 01/2018 - 04/2003
18	Lung Injury 01/2021 - 04/2003
16	Edema (Dropsy) 02/2020 - 04/2003
12	Acute Lung Injury 01/2021 - 02/2004
12	Infections 09/2020 - 12/2009
8	Lung Diseases (Lung Disease) 01/2018 - 03/2012
7	Inflammation (Inflammations) 09/2020 - 03/2012
7	Pulmonary Edema 05/2011 - 01/2002
5	Respiratory Insufficiency (Respiratory Failure) 01/2021 - 02/2002
5	Pneumonia (Pneumonitis) 01/2020 - 09/2006
5	Chronic Obstructive Pulmonary Disease (COPD) 01/2020 - 05/2013
5	Acidosis 02/2017 - 02/2002
4	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2021 - 01/2016
4	Human Influenza (Influenza) 01/2020 - 01/2019
4	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 02/2017 - 02/2004
4	Neoplasms (Cancer) 01/2016 - 09/2013
3	Thrombosis (Thrombus) 02/2019 - 10/2007
2	Asthma (Bronchial Asthma) 10/2020 - 02/2002
2	Wounds and Injuries (Trauma) 01/2020 - 09/2006
2	Idiopathic Pulmonary Fibrosis 01/2019 - 09/2011
2	Heart Failure 01/2019 - 11/2005
2	Respiratory Tract Diseases (Respiratory Tract Disease) 05/2016 - 01/2012
2	Fibrosis (Cirrhosis) 01/2016 - 09/2011
2	Hyperoxia 04/2005 - 05/2002
1	COVID-19 12/2021
1	Nervous System Diseases (Neurological Disorders) 12/2021
1	Arthritis (Polyarthritis) 01/2021
1	Atherosclerosis 01/2021
1	Hypoventilation 10/2020
1	Polycythemia (Erythrocytosis) 01/2018
1	Lung Neoplasms (Lung Cancer) 10/2017

Drug/Important Bio-Agent (IBA)

35	Adenosine Triphosphatases (ATPase)IBA 12/2021 - 01/2002
19	Proteins (Proteins, Gene)FDA Link 01/2021 - 05/2002
10	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2011 - 05/2002
9	UbiquitinIBA 01/2021 - 05/2006
8	CytokinesIBA 12/2021 - 10/2007
6	Interleukin-6 (Interleukin 6)IBA 01/2019 - 04/2005
5	Carbon DioxideIBA 10/2020 - 07/2010
5	AMP-Activated Protein KinasesIBA 12/2015 - 07/2009
4	Messenger RNA (mRNA)IBA 01/2018 - 12/2009
4	Biological ProductsIBA 10/2017 - 02/2015
4	SodiumIBA 05/2011 - 01/2007
3	Adenosine Triphosphate (ATP)IBA 02/2020 - 09/2011
3	Particulate MatterIBA 01/2019 - 06/2006
3	protein kinase C zetaIBA 11/2017 - 07/2009
3	LuciferasesIBA 04/2016 - 07/2010
3	Pharmaceutical PreparationsIBA 09/2013 - 11/2005
3	Small Interfering RNA (siRNA)IBA 09/2010 - 05/2006
3	Dopamine (Intropin)FDA LinkGeneric 07/2006 - 04/2003
3	Mitochondrial DNA (mtDNA)IBA 05/2006 - 05/2002
2	RNA (Ribonucleic Acid)IBA 12/2021 - 01/2019
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2021 - 01/2019
2	Adrenal Cortex Hormones (Corticosteroids)IBA 09/2020 - 01/2020
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 09/2020 - 01/2020
2	ChemokinesIBA 01/2020 - 01/2017
2	Metformin (Glucophage)FDA LinkGeneric 02/2019 - 01/2019
2	Calcium Release Activated Calcium ChannelsIBA 01/2019 - 09/2011
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2018 - 09/2013
2	Protein Kinases (Protein Kinase)IBA 01/2018 - 07/2009
2	Protein Isoforms (Isoforms)IBA 01/2018 - 07/2009
2	Fibronectins (Fibronectin)IBA 10/2017 - 09/2011
2	Epithelial Sodium ChannelsIBA 01/2017 - 01/2007
2	Oxygen (Dioxygen)IBA 05/2016 - 12/2014
2	Antimicrobial PeptidesIBA 01/2016 - 11/2009
2	CatecholaminesIBA 07/2015 - 04/2003
2	LipopolysaccharidesIBA 05/2013 - 07/2010
2	Protein Kinase CIBA 01/2012 - 12/2009
2	Phosphotransferases (Kinase)IBA 09/2011 - 12/2009
2	NF-kappa B (NF-kB)IBA 07/2010 - 11/2009
2	CatalaseIBA 07/2009 - 05/2006
2	Isoproterenol (Isoprenaline)FDA LinkGeneric 02/2008 - 04/2003
2	AntioxidantsIBA 04/2003 - 05/2002
1	Eukaryotic Initiation Factor-2B (Eukaryotic Initiation Factor 2B)IBA 01/2021
1	AcidsIBA 01/2021
1	Lysine (L-Lysine)FDA Link 01/2021
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2021
1	TNF Receptor-Associated Factor 2 (TRAF2)IBA 01/2021
1	Lopinavir FDA Link 01/2021
1	Ritonavir (Norvir)FDA Link 01/2021
1	EnzymesIBA 02/2020
1	Ketoglutaric Acids (Ketoglutaric Acid)IBA 02/2020
1	Membrane Transport Proteins (Biological Pump)IBA 02/2020
1	Cell Adhesion MoleculesIBA 02/2020
1	SmokeIBA 01/2020
1	Adenylate KinaseIBA 01/2020
1	sharpinIBA 01/2020
1	CXCR4 Receptors (CXCR4 Receptor)IBA 01/2020
1	c-Mer Tyrosine KinaseIBA 01/2020
1	tocilizumab (atlizumab)FDA Link 01/2019
1	Cardiac GlycosidesIBA 01/2019
1	Nucleosomes (Nucleosome)IBA 10/2018
1	Erythropoietin FDA Link 01/2018
1	Caspase 7IBA 01/2018

Therapy/Procedure

7	Therapeutics 01/2021 - 03/2014
6	Artificial Respiration (Mechanical Ventilation) 01/2021 - 02/2002
3	Critical Care (Surgical Intensive Care) 04/2015 - 09/2006
2	Mechanical Ventilators (Ventilator) 09/2011 - 02/2002
1	Pneumonectomy (Lung Volume Reduction) 01/2021
1	Transplantation 01/2020